Best Liver Supplements for Cats: Supporting Your Feline’s Liver Health

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Maintaining liver health in cats is crucial for their overall well-being. The liver is an essential organ that detoxifies the blood, processes nutrients, and plays a critical role in metabolism. Unfortunately, liver problems in felines, including fatty liver disease, elevated liver enzymes, and jaundice, can be common and can significantly impact your cat’s quality of life. Prolonged liver issues in cats can bring on lethargy, poor brain function, weight loss, prolonged bleeding from even minor injuries, and organ failure.

According to Preston Turano, DVM and veterinary spokesperson at Felix Cat Insurance, some of those issues are also clinical signs of liver disease. Add to that increased water intake and urination. “These signs are not specific to just liver disease and can indicate another disease process,” Turano adds. “If your cat is showing any of these symptoms, it is best to contact your veterinarian. Jaundice or yellowing of the skin or whites of the eyes strongly suggests underlying liver issues but also can be seen with other disease processes.”

Cats experiencing liver challenges might also have elevated liver enzymes. This is called ALT or alanine aminotransferase and indicates liver stress or damage. Common causes include infections, toxins, fatty liver disease, or underlying conditions like diabetes. If your vet identifies elevated enzymes during a cat liver function test, they may recommend a liver health supplement and further diagnostic testing to pinpoint the cause.

In addition, as cats age or face other health challenges, liver supplements (like Denamarin) for cats become vital tools in promoting healthy liver function and addressing specific conditions. So, even if your cat isn’t experiencing challenges, you may want to use a liver supplement for preventative measures.

According to Dr. Clara Whitmore, veterinarian and in-house advisor at pet health and hygiene company Boxie Cat, “Liver supplements have many positive effects on cats, particularly when the organ cannot perform its functions as usual. They support liver regeneration and detoxification and protect the organ from oxidative damage caused by free radicals.” Whitmore continues that liver supplements can also reduce liver inflammation.

However, Whitmore cautions that supplements should not be considered a treatment replacement. There are also potential side effects to be aware of when giving your cat liver supplements. “Some cats may experience mild digestive upset, such as diarrhea or vomiting, when introduced to a new supplement,” Whitmore says. “It’s important to start with a small dose and gradually increase it to see how your cat responds.”

Whitmore also reminds us that some supplement ingredients could lead to irritability in some cats.

What Is Denamarin for Cats?

Denamarin for cats is one of the most popular and effective liver health supplements. It contains two powerful ingredients: SAM-e (S-adenosylmethionine) and silybin, a component of milk thistle for cats. These ingredients work to improve liver function, support detoxification, and protect liver cells from damage.

SAM-e boosts the liver’s ability to produce antioxidants, which combat oxidative stress—a key factor in liver damage. Silybin, extracted from milk thistle, promotes cell regeneration and protects against toxins. Together, these components offer comprehensive feline liver support, so it’s no wonder that Denamarin has become a top choice for many veterinarians.

If you have reservations and wonder if you can give your cat milk thistle made for humans, you should consider one thing. While milk thistle is a beneficial herb for cats, you should avoid giving your pet milk thistle supplements formulated for humans. Human dosages and additional ingredients in these products are not safe for cats. Always choose milk thistle explicitly formulated for cats, like Denamarin.

As always, whether you’re giving your cat Denamarin or any other supplement, consult with your vet, says Josh Wiesenfeld, pet expert and founder of Boxiecat. “Supplements can be [given to pets], but not at the expense of proper veterinary care. Your vet will know best if your cat needs supplements and can suggest which will be the most beneficial. They will be able to monitor the health of the liver and change treatment when necessary.”

Liver Supplements for Cats: Our Top Picks

To help narrow your options, we curated our top picks for the best cat liver supplements. We evaluated their ingredients, effectiveness, and recommendations from trusted veterinarians. Products like Denamarin stand out for their proven ability to support liver health with key components like SAM-e and milk thistle. We prioritized supplements that have positive reviews, are highly rated by pet owners, and are easy to administer.

• Best Overall Liver Supplement for Cats: Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Small Dogs & Cats
• Best Liver Supplement for Cats in Liquid Form: Pet Wellbeing Milk Thistle Liquid Liver Dog & Cat Supplement
• Best Cat Liver Supplement on a Budget: VetriScience Vetri Liver Feline Milk Thistle Supplement for Cats
• Best Cat Liver Supplement Good for Cognitive Function Too: Coco and Luna SAMe + Silybin for Cats
• Most Responsibly Formulated Cat Liver Supplement: Fera Pet Organics Liver Supplement for Dogs & Cats
• Most Gentle Formula Liver Supplement for Cats: HomeoPet Liver Rescue, Safe and Natural Liver Support for Pets

Best Overall Liver Supplement for Cats

Our Pick: Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Small Dogs & Cats

Denamarin supports your pet’s liver health with SAMe, which boosts glutathione levels for detoxification, and silybin, a highly absorbable milk thistle extract. This supplement from trusted brand Nutramax Laboratories (which has been operating for over 30 years) promotes the liver’s essential functions, including toxin removal, digestion, and immune support, for both dogs and cats. In coated tablet form, this supplement is veterinarian-formulated with high-quality ingredients.

Highlights

• Many pet parents appreciate the small, coated tablets, which are easier for pets to swallow.
• Pet owners said they saw noticeable results and that this effectively reduced liver enzyme levels and improved overall liver function in cats.
• Made of all-natural milk thistle formula, it appeals to pet parents who prioritize clean, natural options.

Things to Consider

• Some cats are fickle about tablets; they might find the taste of the outside unpleasant.
• A few pets may experience stomach discomfort or vomiting while getting used to this supplement.

Best Liver Supplement for Cats in Liquid Form

Our Pick: Pet Wellbeing Milk Thistle Liquid Liver Dog & Cat Supplement

This natural, gentle supplement is meant to provide powerful liver-supporting properties in dogs and cats. Its active compounds, silymarins, will protect against toxins, promote new liver cell growth, and provide antioxidant benefits stronger than vitamin E. PetWellbeing’s organic formula also adheres to strict FDA and veterinary guidelines, so you can be confident this meets safety, potency, and quality standards for long-term use.

Highlights

• This milk thistle helps protect liver cells from free radical damage and toxins while supporting the regeneration of new, healthy liver cells.
• This supplement also provides potent antioxidant benefits (stronger than vitamin E) to help reduce inflammation and promote overall liver health.
• This glycerin-based supplement is formulated without alcohol and adheres to strict FDA and veterinary guidelines, and can be combined with other medications.

Things to Consider

• It may not be enough to address severe liver conditions or advanced diseases without additional veterinary treatments.
• Some pets may experience mild digestive issues, such as diarrhea or upset stomach, especially when starting the supplement.

Best Cat Liver Supplement on a Budget

Our Pick: VetriScience Vetri Liver Feline Milk Thistle Supplement for Cats

VetriScience Vetri Liver Feline Milk Thistle Supplement’s comprehensive formula is designed to support your cat’s liver health through detoxification, fat metabolism, and antioxidant protection. Key ingredients include glutathione, SAMe, taurine, and B vitamins, which all work together to promote normal liver function, bile production, and toxin neutralization. If your cat has liver issues, this supplement supports overall health and recovery, making it a thoughtful addition to their care routine.

Highlights

• With 15 synergistic ingredients, including glutathione, taurine, and SAMe, this supplement promotes liver detoxification, fat metabolism, and antioxidant protection.
• They come as chicken-flavored chews, so cats will probably have no problem eating them.
• The formula is crafted to be compatible with cats who have sensitive digestive systems or specific dietary needs.

Things to Consider

• While the chews are flavored, some cats may still be picky and refuse to eat them, making administration challenging.
• Like many supplements, starting this product may cause minor stomach issues, such as diarrhea, in some cats.

Best Cat Liver Supplement Good for Cognitive Function Too

Our Pick: Coco and Luna SAMe + Silybin for Cats

Coco and Luna’s SAMe Silybin for Cats provides dual benefits by promoting liver health and enhancing cognitive function. The powder combines SAMe and Silybin to aid liver detoxification, protect against damage, and support brain activity, keeping your cat physically active and mentally sharp. Veterinarian-formulated with natural ingredients, it’s an excellent choice for cats with both liver issues and those needing cognitive support.

Highlights

• Combines SAMe and Silybin to detoxify the liver, protect against damage, and enhance cognitive function.
• Made without harmful additives like palm oil, synthetic colors, or artificial flavors.
• The salmon-flavored powder (a favorite for many cats) can be mixed into food.

Things to Consider

• While flavored, some cats may still reject the powder, making administration challenging for certain picky eaters.
• When first starting the supplement, a small number of cats may experience mild stomach issues, such as diarrhea or vomiting.

Most Responsibly Formulated Cat Liver Supplement

Our Pick: Fera Pet Organics Liver Supplement for Dogs & Cats

Fera Pet Organics Liver Supplement stands out with its unique blend of Eastern and Western ingredients, including milk thistle, turmeric, and organic herbs like burdock and dandelion. Together, the formula is designed to promote liver detoxification and overall health. Crafted by a veterinarian, this chicken bone broth-flavored powder supports liver function while avoiding fillers, dyes, and preservatives. Its NASC quality seal ensures high standards, making it an excellent choice for cats with liver issues seeking a holistic and effective supplement.

Highlights

• Formulated by a vet and bearing the NASC quality seal, ensuring safety and high standards for your cat’s health.
• Includes BioPerine black pepper extract to boost nutrient absorption, maximizing the supplement’s effectiveness.

Things to Consider

• Despite its chicken bone broth flavor, some picky cats might resist the powdered form when mixed with food.
• Unlike tablets or chews, this powder requires consistent mixing into food, which could be inconvenient for some pet parents.

Most Gentle Formula Liver Supplement for Cats

Our Pick:  HomeoPet Liver Rescue, Safe and Natural Liver Support for Pets

HomeoPet Liver Rescue offers cats natural and safe liver support, promoting detoxification and healthy liver, kidney, and digestive function. Its gentle, homeopathic formula is suitable for cats of all ages, even small pets like rabbits or birds. Unlike others, it’s a liquid supplement, making dosing easy—just add it to water or meals or administer it directly, ensuring convenience and flexibility for pet parents.

Highlights

• Made with gentle homeopathic ingredients.
• Based on reviews, pet owners haven’t mentioned any known side effects.
• Suitable for pets of all ages and sizes, even small animals like rabbits and birds.
• It promotes healthy kidney and digestive functions for comprehensive wellness and liver support.

Things to Consider

• It must be administered twice daily for 21 days, which might be challenging for busy pet owners.
• As a homeopathic remedy, results may differ significantly between pets, and it might not address severe liver issues as effectively as targeted treatments.

Liver Supplement Buying Guide

Before you give your cat a liver supplement, assess your fur baby’s health. Early detection of liver issues in cats is important. How will you know it’s time to consult your vet to learn more? Symptoms to watch for include:

• Appetite loss
• Vomiting
• Lethargy
• Jaundice (yellowing of the eyes or skin)
• Weight loss

If you notice the signs above, consult your veterinarian for a diagnosis and a cat liver function test. Your vet might also do a blood test to see if your cat has high bilirubin, which is another indication of a liver issue.

Should the vet discover that your cat needs liver support, consider some factors and ask for more information before you move forward with a supplement. Younger cats with mild issues, for instance, may require lower doses, while senior cats or those with significant liver problems may need more robust support. You should also mention any other medications or treatments your cat may receive to ensure it won’t interfere with a liver supplement.

Always advocate for your pet by asking all of the questions you have before you start giving your pet supplements. Your veterinarian should help you determine the appropriate product and dosage.

Key Ingredients to Look For in Liver Supplements for Cats

If your veterinarian discovers that your pet is dealing with a liver issue, they will recommend supplements. You can also do your research in tandem. According to the experts we interviewed, when choosing the best liver supplements for cats, prioritize products with:

• SAM-e, which boosts antioxidant production and supports cell repair
• Milk thistle for cats (Silybin), which protects liver cells and aids regeneration
• Vitamin E, which reduces inflammation and oxidative stress
• Phosphatidylcholine, which supports cell membrane integrity and liver function

Turano also cautions the ideal “supplement choice often depends on the underlying cause of the disease.” She continues, “Liver disease is a complex process with many underlying causes that require different treatments. It is best to consult your vet about the treatment or supplements appropriate for your cat’s specific liver issue.”

Choosing the Right Liver Supplement Format

Liver supplements for cats come in tablets, liquids, and powders. Liquids and powders may be the easiest to mix with food for picky eaters. Tablets, on the other hand, give you precise dosing. At the end of the day, you know your cat best. Pick the format that ensures your fur baby will consume the supplement.

Other Tips for Supporting Your Cat’s Liver Health

Once your vet has determined that you should give your cat a liver supplement, introduce it gradually to your cat’s routine. From there, administer it consistently daily to build a habit. Some supplements, like Denamarin for cats, require fasting before administration, so follow the instructions carefully.

Supplements are not the only solution to helping your cat stay healthy. Routine vet visits and diagnostic tests are crucial for monitoring your cat’s liver. Regular checkups can help detect elevated liver enzymes, fatty liver symptoms, and other liver issues before they progress.

You should also make sure your cat eats balanced meals. “One of the best ways to prevent liver disease is maintaining a healthy weight,” says Turano. “Feeding a healthy diet, regular exercise, plenty of snuggle time, and a preventive health plan will all help your cat to live a long life.”

Feed your cat a high-quality diet rich in protein and low fillers to reduce liver strain. “Look out for foods rich in antioxidants, such as vitamins E and C, which provide protection against oxidative damage in the liver,” says Wiesenfeld. “Foods with sufficient levels of taurine, an amino acid integral to liver health, should also be considered.”

Wiesenfeld adds, “This is why it’s so important not to feed your cat on a highly fattened or protein-laden diet that would burden the liver unnecessarily, especially if a predisposing condition is present.”

Like humans, cats also need to stay hydrated. Make sure your cat stays hydrated to support detoxification. A water fountain might entice them to drink more water than usual. Exercise will also be key. Encourage your cat to play regularly to maintain a healthy weight. As obesity increases, so does the risk of liver problems, so keep your fur baby moving.

A Final Word About Liver Supplements for Cats

Liver supplements for cats, such as Denamarin, provide essential support for your feline’s liver health, especially when dealing with elevated liver enzymes or liver disease. With ingredients like SAM-e, milk thistle for cats, and vitamin E, these supplements protect and repair the liver while supporting detoxification.

By recognizing the signs of liver issues early in your cat, consulting your vet, and incorporating a liver health supplement into your cat’s routine, you can help your furry friend stay healthy and happy.